Oral Prostaglandins in the Induction of Labour

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Oral prostaglandins in the induction of labour.

Prostaglandins E(2) and F(2)alpha were administered by mouth to induce labour in 24 patients at or past term. The drugs were administered at two-hourly intervals in doses ranging from 0.5 to 1.5 mg for prostaglandin E(2) and from 5 to 15 mg for prostaglandin F(2)alpha. Of the 10 cases in which prostaglandin E(2) was used, labour was successfully induced in eight and there were no side effects. ...

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The role of prostaglandins in ripening of cervix, induction of labour and control of Postpartum Haemorrhage

Recently, investigators have shown the use of alternative prostaglandin PGE1 Misoprostol for cervical ripening and induction of labour.1,2 It is prostaglandin E1 analogue, which was introduced as the treatment of gastric ulcer, but later on FDA approved a new label for the use of Misoprostol during pregnancy.3 It has been used for many years for the first and second trimesters of pregnancy term...

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Simplifying oral misoprostol protocols for the induction of labour

Induction of labour is carried out worldwide for a broad range of maternal and fetal indications, so as to improve pregnancy outcomes. Oral misoprostol has been widely discussed as a method of labour induction. It is recommended for this indication by the World Health Organization (WHO), the International Federation of Gynecology and Obstetrics (FIGO), and the Society of Obstetricians and Gynae...

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Role of the prostaglandins in labour and prostaglandin receptor inhibitors in the prevention of preterm labour.

Parturition is composed of five separate but integrated physiological events: fetal membrane rupture, cervical dilatation, myometrial contractility, placental separation, and uterine involution. Prostaglandins (PGs) have central roles in each of these events, but the most studied is myometrial contraction. Elevated uterine PGs or the enhanced sensitivity of the myometrium to PGs leads to contra...

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ژورنال

عنوان ژورنال: BMJ

سال: 1972

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.5807.188